2023


  1. Abdul Majeed S, Dunzendorfer H, Weiner J, Heiker JT, Kiess W, Körner A, Landgraf K (2023). COBL, MKX and MYOC Are Potential Regulators of Brown Adipose Tissue Development Associated with Obesity-Related Metabolic Dysfunction in Children. Int J Mol Sci, 24(4), 3085.
     
  2. Körner A, Stein R, Landgraf K (2023). Beyond genetic screening-functionality-based precision medicine in monogenic obesity. Lancet Diabetes Endocrinol, 11(3), 143-144.
     
  3. Ott R, Stein R, Hauta-Alus HH, Ronkainen J, Fernández-Barrés S, Spielau U, Kirsten H, Poulain T, Melton PE, Küpers LK, Azaryah H, Colombo M, Landgraf K, Tobi EW, O'Sullivan T, Huang RC, Campoy C, Winkler C, Vioque J, Vrijheid M, Kiess W, Körner A, Sebert S, Jarvelin MR, Ziegler AG, Hummel S (2023). Epigenome-Wide Meta-analysis Reveals Associations Between Dietary Glycemic Index and Glycemic Load and DNA Methylation in Children and Adolescents of Different Body Sizes. Diabetes Care, 46(11), 2067-2075.
     
  4. Kaczmarek I, Wower I, Ettig K, Kuhn CK, Kraft R, Landgraf K, Körner A, Schöneberg T, Horn S, Thor D (2023). Identifying G protein-coupled receptors involved in adipose tissue function using the innovative RNA-seq database FATTLAS. iScience, 26(10), 107841.
     
  5. Landgraf K, Garten A, Kirstein AS (2023). Das Pädiatrische Forschungszentrum. In: Kiess W, Zukunft hat Herkunft. (S. 187-191), Leipzig: Leipziger Universitätsverlag.
     


    6. 2022


  6. Kempf E#, Landgraf K#, Stein R, Hanschkow M, Hilbert A, Abou Jamra R, Boczki P, Herberth G, Kühnapfel A, Tseng YH, Stäubert C, Schöneberg T, Kühnen P, Rayner NW, Zeggini E, Kiess W, Blüher M, Körner A (2022). Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity. (#contributed equally) Nat Metab, 4(12), 1697-1712.
     
  7. Kempf E, Landgraf K, Vogel T, Spielau U, Stein R, Raschpichler M, Kratzsch J, Kiess W, Stanik J, Körner A (2022). Associations of GHR, IGF-1 and IGFBP-3 expression in adipose tissue cells with obesity-related alterations in corresponding circulating levels and adipose tissue function in children. Adipocyte, 11(1), 630-642.
     
  8. Landgraf K#, Kühnapfel A#, Schlanstein M, Biemann R, Isermann B, Kempf E, Kirsten H, Scholz M, Körner A (2022). Transcriptome Analyses of Adipose Tissue Samples Identify EGFL6 as a Candidate Gene Involved in Obesity-Related Adipose Tissue Dysfunction in Children. (#contributed equally) Int J Mol Sci, 23(8), 4349.
     
  9. Hanschkow M, Boulet N, Kempf E, Bouloumié A, Kiess W, Stein R, Körner A, Landgraf K (2022). Expression of the Adipocyte Progenitor Markers MSCA1 and CD36 is Associated With Adipose Tissue Function in Children. J Clin Endocrinol Metab, 107(2), e836-e851.
     
  10. Hoang AC, Sasi-Szabó L, Pál T, Szabó T, Diedrich V, Herwig A, Landgraf K, Körner A, Röszer T (2022). Mitochondrial RNA stimulates beige adipocyte development in young mice. Nat Metab, 4(12), 1684-1696.
     
  11. Yang CH, Fagnocchi L, Apostle S, Wegert V, Casaní-Galdón S, Landgraf K, Panzeri I, Dror E, Heyne S, Wörpel T, Chandler DP, Lu D, Yang T, Gibbons E, Guerreiro R, Bras J, Thomasen M, Grunnet LG, Vaag AA, Gillberg L, Grundberg E, Conesa A, Körner A, Pospisilik JA (2022). Independent phenotypic plasticity axes define distinct obesity sub-types. Nat Metab, 4(9), 1150-1165.
     
  12. Thrum S, Sommer M, Raulien N, Gericke M, Massier L, Kovacs P, Krasselt M, Landgraf K, Körner A, Dietrich A, Blüher M, Rossol M, Wagner U (2022). Macrophages in obesity are characterised by increased IL-1? response to calcium-sensing receptor signals. Int J Obes (Lond), 46(10), 1883-1891.
     
  13. Küpers LK, Fernández-Barrés S, Mancano G, Johnson L, Ott R, Vioque J, Colombo M, Landgraf K, Tobi EW, Körner A, Gaillard R, de Vries JHM, Jaddoe VWV, Vrijheid M, Sharp GC, Felix JF (2022). Maternal Dietary Glycemic Index and Glycemic Load in Pregnancy and Offspring Cord Blood DNA Methylation. Diabetes Care, 45(8), 1822-1832.
     
  14. Christen L, Broghammer H, Rapöhn I, Möhlis K, Strehlau C, Ribas-Latre A, Gebhardt C, Roth L, Krause K, Landgraf K, Körner A, Rohde-Zimmermann K, Hoffmann A, Klöting N, Ghosh A, Sun W, Dong H, Wolfrum C, Rassaf T, Hendgen-Cotta UB, Stumvoll M, Blüher M, Heiker JT, Weiner J (2022). Myoglobin-mediated lipid shuttling increases adrenergic activation of brown and white adipocyte metabolism and is as a marker of thermogenic adipocytes in humans. Clin Transl Med, 12(12), 1108.
     


    15. 2021


  15. Kempf E, Vogel M, Vogel T, Kratzsch J, Landgraf K, Kühnapfel A, Gausche R, Gräfe D, Sergeyev E, Pfäffle R, Kiess W, Stanik J, Körner A (2021). Dynamic alterations in linear growth and endocrine parameters in children with obesity and height reference values. EClinicalMedicine, 37, 100977.
     
  16. Kirstein AS, Kehr S, Nebe M, Hanschkow M, Barth LAG, Lorenz J, Penke M, Breitfeld J, Le Duc D, Landgraf K, Körner A, Kovacs P, Stadler PF, Kiess W, Garten A (2021). PTEN regulates adipose progenitor cell growth, differentiation, and replicative aging. J Biol Chem, 297(2), 100968.
     
  17. Schaffert A, Krieg L, Weiner J, Schlichting R, Ueberham E, Karkossa I, Bauer M, Landgraf K, Junge KM, Wabitsch M, Lehmann J, Escher BI, Zenclussen AC, Körner A, Blüher M, Heiker JT, von Bergen M, Schubert K (2021). Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation. Environ Int, 156(), 106730.
     


    18. 2020


  18. Kässner F, Kirstein A, Händel N, Schmid GL, Landgraf K, Berthold A, Tannert A, Schaefer M, Wabitsch M, Kiess W, Körner A, Garten A (2020). A new human adipocyte model with PTEN haploinsufficiency. Adipocyte, 9(1), 290-301.
     
  19. Voigtmann F, Wolf P, Landgraf K, Stein R, Kratzsch J, Schmitz S, Abou Jamra R, Blüher M, Meiler J, Beck-Sickinger AG, Kiess W, Körner A (2020). Identification of a novel leptin receptor (LEPR) variant and proof of functional relevance directing treatment decisions in patients with morbid obesity. Metabolism, 116, 154438.
     
  20. Kalkhof S, Krieg L, Büttner P, Wabitsch M, Küntzel C, Friebe D, Landgraf K, Hanschkow M, Schubert K, Kiess W, Krohn K, Blüher M, von Bergen M, Körner A (2020). In Depth Quantitative Proteomic and Transcriptomic Characterization of Human Adipocyte Differentiation Using the SGBS Cell Line. Proteomics, (20), e1900405.
     
  21. Landgraf K, Klöting N, Gericke M, Maixner N, Guiu-Jurado E, Scholz M, Witte AV, Beyer F, Schwartze JT, Lacher M, Villringer A, Kovacs P, Rudich A, Blüher M, Kiess W, Körner A (2020). The Obesity-Susceptibility Gene TMEM18 Promotes Adipogenesis through Activation of PPARG. Cell Rep, 33(3), 108295.
     
  22. Suchý T, Zieschang C, Popkova Y, Kaczmarek I, Weiner J, Liebing AD, Çakir MV, Landgraf K, Gericke M, Pospisilik JA, Körner A, Heiker JT, Dannenberger D, Schiller J, Schöneberg T, Liebscher I, Thor D (2020). The repertoire of Adhesion G protein-coupled receptors in adipocytes and their functional relevance. Int J Obes (Lond), 44(10), 2124-2136.
     
  23. Tsaban G, Yaskolka Meir A, Rinott E, Zelicha H, Kaplan A, Shalev A, Katz A, Rudich A, Tirosh A, Shelef I, Youngster I, Lebovitz S, Israeli N, Shabat M, Brikner D, Pupkin E, Stumvoll M, Thiery J, Ceglarek U, Heiker JT, Körner A, Landgraf K, von Bergen M, Blüher M, Stampfer MJ, Shai I (2020). The effect of green Mediterranean diet on cardiometabolic risk; a randomised controlled trial. Heart, (0), 0.
     
  24. Suchý T, Zieschang C, Popkova Y, Kaczmarek I, Weiner J, Liebing AD, Çakir MV, Landgraf K, Gericke M, Pospisilik JA, Körner A, Heiker JT, Dannenberger D, Schiller J, Schöneberg T, Liebscher I, Thor D (2020). The repertoire of Adhesion G protein-coupled receptors in adipocytes and their functional relevance. Int J Obes (Lond), 44(10), 2124-2136.
     
  25. Shamsi F, Xue R, Huang TL, Lundh M, Liu Y, Leiria LO, Lynes MD, Kempf E, Wang CH, Sugimoto S, Nigro P, Landgraf K, Schulz T, Li Y, Emanuelli B, Kothakota S, Williams LT, Jessen N, Pedersen SB, Böttcher Y, Blüher M, Körner A, Goodyear LJ, Mohammadi M, Kahn CR, Tseng YH (2020). FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis. Nat Commun, 11(1), 1421.
     
  26. Krieg L, Schaffert A, Kern M, Landgraf K, Wabitsch M, Beck-Sickinger AG, Koerner A, Blüher M, von Bergen M, Schubert K (2020). An MRM-Based Multiplexed Quantification Assay for Human Adipokines and Apolipoproteins. Molecules, 25(4), 775.
     


    27. 2019


  27. Stanik J, Kratzsch J, Landgraf K, Vogel M, Thiery J, Kiess W, Körner A (2019). The Bone Markers Sclerostin, Osteoprotegerin, and Bone-Specific Alkaline Phosphatase Are Related to Insulin Resistance in Children and Adolescents, Independent of Their Association with Growth and Obesity. Horm Res Paediatr, 91(1), 1-8.
     
  28. Landgraf K, Kiess W, Körner A (2019). Frühe Fettgewebsdysfunktion bei Kindern mit Adipositas. Adipositas, 13, 14-22.
     
  29. Landgraf K, Kiess W, Körner A (2019). Frühe Fettgewebsdysfunktion bei Kindern mit Adipositas. Adipositas, 13, 14-22.
     
  30. Yu H, Dilbaz S, Cossmann J, Hoang AC, Diedrich V, Herwig A, Harauma A, Hoshi Y, Moriguchi T, Landgraf K, Körner A, Lucas C, Brodesser S, Balogh L, Thuroczy J, Karemore G, Kuefner MS, Park EA, Rapp C, Travers JB, Roszer T (2019). Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages. J Clin Invest, 129(6), 2485-2499.
     
  31. Schulz A, Brendler J, Blaschuk O, Landgraf K, Krueger M, Ricken AM (2019). Non-pathological Chondrogenic Features of Valve Interstitial Cells in Normal Adult Zebrafish. J Histochem Cytochem, 67(5), 361-373.
     


    32. 2018


  32. Kalenda A, Landgraf K, Löffler D, Kovacs P, Kiess W, Körner A (2018). The BDNF Val66Met polymorphism is associated with lower BMI, lower postprandial glucose levels and elevated carbohydrate intake in children and adolescents. Pediatr Obes, 13(3), 159-167.
     
  33. Kässner F, Sauer T, Penke M, Richter S, Landgraf K, Körner A, Kiess W, Händel N, Garten A (2018). Simvastatin induces apoptosis in PTEN?haploinsufficient lipoma cells. Int J Mol Med, 41(6), 3691-3698.
     
  34. Landgraf K, Kiess W, Körner A (2018). Der Zebrafisch als in vivo-Modellsystem für Adipositas und assoziierte Erkrankungen. Adipositas, 12, 198-203.
     
  35. Junge KM, Leppert B, Jahreis S, Wissenbach DK, Feltens R, Grützmann K, Thürmann L, Bauer T, Ishaque N, Schick M, Bewerunge-Hudler M, Roder S, Bauer M, Schulz A, Borte M, Landgraf K, Körner A, Kiess W, (2018). MEST mediates the impact of prenatal bisphenol A exposure on long-term body weight development. Clin Epigenetics, 10, 58-.
     
  36. Körner A, Kiess W, Landgraf K (2018). White Adipose Tissue Accumulation and Dysfunction in Children with Obesity. In: Freemark M, Pediatric Obestiy. Contemporary Endocrinology. (S. 95-116), Cham: Humana Press.
     
  37. Landgraf K, Penke M (2018). Translationale Forschung in der Kinderheilkunde und Jugendmedizin an der Universitätskinderklinik in Leipzig. In: Kiess W, 125 Jahre Universitätskinderklinik Leipzig. (S. 75-78), Leipzig: Leipziger Universitätsverlag.
     


    38. 2017


  38. Stanik J, Kratzsch J, Landgraf K, Scheuermann K, Spielau U, Gausche R, Gasperikova D, Kiess W, Körner A (2017). Concordance of bioactive vs. total immunoreactive serum leptin levels in children with severe early onset obesity. PLoS One, 12(5), e0178107.
     
  39. Landgraf K, Schuster S, Meusel A, Garten A, Riemer T, Schleinitz D, Kiess W, Körner A (2017). Short-term overfeeding of zebrafish with normal or high-fat diet as a model for the development of metabolically healthy versus unhealthy obesity. BMC Physiol, 17(1), 4.
     
  40. Schwartze JT, Landgraf K, Spielau U, Rockstroh D, Löffler D, Kratzsch J, Kiess W, Körner A (2017). Adipocyte C1QTNF5 expression is BMI-dependently related to early adipose tissue dysfunction and systemic CTRP5 serum levels in obese children. Int J Obes (Lond), 41(6), 955-963.
     
  41. Löffler D, Landgraf K, Rockstroh D, Schwartze JT, Dunzendorfer H, Kiess W, Körner A (2017). METRNL decreases during adipogenesis and inhibits adipocyte differentiation leading to adipocyte hypertrophy in humans. Int J Obes (Lond), 41(1), 112-119.
     


    42. 2016


  42. Schreier M, Schwartze JT, Landgraf K, Scheuermann K, Erbs S, Herberth G, Pospisilik JA, Kratzsch J, Kiess W, Körner A (2016). Osteopontin is BMI-independently Related to Early Endothelial Dysfunction in Children. J Clin Endocrinol Metab, 101(11), 4161-4169.
     
  43. Landgraf K, Strobach A, Kiess W, Körner A (2016). Loss of mtch2 function impairs early development of liver, intestine and visceral adipocytes in zebrafish larvae. FEBS Lett, 590(17), 2852-2861.
     
  44. Landgraf K, Scholz M, Kovacs P, Kiess W, Körner A (2016). FTO Obesity Risk Variants Are Linked to Adipocyte IRX3 Expression and BMI of Children - Relevance of FTO Variants to Defend Body Weight in Lean Children? PLoS One, 11(8), e0161739.
     
  45. Rockstroh D, Löffler D, Kiess W, Landgraf K, Körner A (2016). Regulation of human adipogenesis by miR125b-5p. Adipocyte, 5(3), 283-297.
     
  46. Löffler D, Landgraf K, Körner A, Kratzsch J, Kirkby KC, Himmerich H (2016). Modulation of triglyceride accumulation in adipocytes by psychopharmacological agents in vitro. J Psychiatr Res, 72, 37-42.
     
  47. Guiu-Jurado E, Unthan M, Böhler N, Kern M, Landgraf K, Dietrich A, Schleinitz D, Ruschke K, Klöting N, Fasshauer M, Tönjes A, Stumvoll M, Köner A, Kovacs P, Blüher M (2016). Bone morphogenetic protein 2 (BMP2) may contribute to partition of energy storage into visceral and subcutaneous fat depots. Obesity (Silver Spring), 24(10), 2092-2100.
     
  48. Dalgaard K, Landgraf K, Heyne S, Lempradl A, Longinotto J, Gossens K, Ruf M, Orthofer M, Strogantsev R, Selvaraj M, Lu TT, Casas E, Teperino R, Surani MA, Zvetkova I, Rimmington D, Tung YC, et al (2016). Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity. Cell, 164(3), 353-364.
     


    49. 2015


  49. Rockstroh D, Landgraf K, Wagner IV, Gesing J, Tauscher R, Lakowa N, Kiess W, Bühligen U, Wojan M, Till H, Blüher M, Körner A (2015). Direct evidence of brown adipocytes in different fat depots in children. PLoS One, 10(2), e0117841.
     
  50. Landgraf K, Rockstroh D, Wagner IV, Weise S, Tauscher R, Schwartze JT, Löffler D, Bühligen U, Wojan M, Till H, Kratzsch J, Kiess W, Blüher M, Körner A (2015). Evidence of early alterations in adipose tissue biology and function and its association with obesity-related inflammation and insulin resistance in children. Diabetes, 64(4), 1249-1261.
     
  51. Löffler D, Müller U, Scheuermann K, Friebe D, Gesing J, Bielitz J, Erbs S, Landgraf K, Wagner IV, Kiess W, Körner A (2015). Serum irisin levels are regulated by acute strenuous exercise. J Clin Endocrinol Metab, 100(4), 1289-1299.
     


    52. 2014


  52. Musharraf A, Kruspe D, Tomasch J, Besenbeck B, Englert C, Landgraf K (2014). BOR-syndrome-associated Eya1 mutations lead to enhanced proteasomal degradation of Eya1 protein. PLoS One, 9(1), 387407.
     


    53. 2013


  53. Bernhard F, Landgraf K, Klöting N, Berthold A, Büttner P, Friebe D, Kiess W, Kovacs P, Blüher M, Körner A (2013). Functional relevance of genes implicated by obesity genome-wide association study signals for human adipocyte biology. Diabetologia, 56(2), 311-322.
     


    54. 2012


  54. Landgraf K, Friebe D, Ullrich T, Kratzsch J, Dittrich K, Herberth G, Adams V, Kiess W, Erbs S, Körner A (2012). Chemerin as a mediator between obesity and vascular inflammation in children. J Clin Endocrinol Metab, 97(4), 556-564.
     


    55. 2011


  55. Friebe D, Loeffler D, Schoenberg M, Bernhard F, Buettner P, Landgraf K, Kiess W, Koerner A (2011). Impact of metabolic regulators on the expression of the obesity associated genes FTO and NAMPT in human preadipocytes and adipocytes. PLoS One, 6(6), e19526.
     


    56. 2010


  56. Landgraf K, Bollig F, Trowe MO, Besenbeck B, Ebert C, Kruspe D, Kispert A, Hänel F, Englert C (2010). Sipl1 and Rbck1 are novel Eya1-binding proteins with a role in craniofacial development. Mol Cell Biol, 30(24), 5764-5775.